Two sample MR report
TTC39C_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.2084459 | 0.2109432 | 0.3959266 |
| Weighted median | 5 | 0.0352877 | 0.0263554 | 0.1805980 |
| Inverse variance weighted | 5 | 0.0467552 | 0.0207846 | 0.0244797 |
| Simple mode | 5 | 0.0332838 | 0.0341416 | 0.3848232 |
| Weighted mode | 5 | 0.0324201 | 0.0307441 | 0.3511303 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2395969 | 3 | 0.9709572 |
| Inverse variance weighted | 1.7175844 | 4 | 0.7875210 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1902105 | 0.1564585 | 0.3110294 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 6.26e-05 | 0 | TRUE | 0.4541611 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
